CD34


Item no.	20-783-71024
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	FC, IP
Clone	MEC14. 7
Specific against	other
ECLASS 5.1	32160702
ECLASS 6.1	32160702
ECLASS 8.0	32160702
ECLASS 9.0	32160702
ECLASS 10.0.1	32160702
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-24F631
Similar products	20-783-71024
Available
Genway ID:	GWB-24F631
Specificity:	CD34NCBI
Gene ID:	12490
Specificity:	CD34
Clone:	MEC14. 7
Specificity Note:	This product recognises the murine CD34 cell surface antigen which is expressed by endothelial cells and by haematopoietic stem cells. This antibody recognises a neuraminidase sensitive epitope. As in the human system CD34 antibodies in the mouse demonstrate slightly different staining patterns depending on their fine specificity. Clone MEC14. 7 appears to recognise a subset of the stem cell population recognised by clone RAM34 and it is thought that this is due to differences in the epitope recognised by the two antibodies.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1/25 - 1/50Immunoprecipitation - 2ug/ml - 10ug/ml
Function:	Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Developmental Stage: On early hematopoietic progenitor cells.
Ptm:	Highly glycosylated.
Ptm:	Phosphorylated on serine residues by PKC.
Disease:	Abnormal CD34 expression in leukemogenesis.
Similarity:	Belongs to the CD34 family. 1. Garlanda. C. et al. (1997) Characterization of MEC14. 7. a new monoclonal antibody recognising mouse CD34: a useful reagent for identifying and characterizing blood vessels and haematopoietic precursors. 2. Winding. B. et al. (2002) Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 8/9/2024

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