CD44v4


Item no.	20-783-70856
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Applications	FC, IHC
Clone	VFF-11
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5D3C52
Similar products	20-783-70856
Available
Genway ID:	GWB-5D3C52
Specificity:	CD44v4
Specificity:	CD44v4
Clone:	VFF-11
Specificity Note:	This product specifically recognises an epitope encoded by exon v4 on the variant portion of human CD44.
Immunohistology:	This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 01%ThimerosalSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - 1:50Immunohistology - Frozen - 1:50 - 1:500
Function:	Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA and possibly also through its affinity for other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration tumor growth and progression. Also involved in lymphocyte activation recirculation and homing and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Subunit:	Interacts with HA as well as other glycosaminoglycans collagen laminin and fibronectin via its N-terminal segment. Interacts with ANK the ERM proteins (VIL2 RDX and MSN) and NF2 via its C-terminal segment.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
Ptm:	Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
Ptm:	N-glycosylated.
Ptm:	O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans whose number may affect the accessibility of specific proteinases to their cleavage site(s).
Ptm:	Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site) and the phosphorylation of Ser-672.
Polymorphism:	CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B) the most frequent allele has Arg-46.
Similarity:	Contains 1 Link domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 0.1 mg

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Delivery expected until 9/13/2024

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