CD152


Item no.	20-783-70851
Manufacturer	GENWAY
Amount	0.2 mg
Category	Oncology Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	FC, IHC
Clone	BNI3
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5EDFCF
Similar products	20-783-70851
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Genway ID:	GWB-5EDFCF
Specificity:	CD152NCBI
Gene ID:	1493
Specificity:	CD152
Clone:	BNI3
Immunogen:	Human CTLA-4/human IgG heavy chain fusion protein
Fusion Partner:	Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3/X63-Ag8. 653 myeloma cell line.
Specificity Note:	This product recognises the human CD152 cell surface antigen also known as CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4). CD152 is a 45kD glycoprotein expressed normally as a disulphide-linked homodimer. It is expressed transiently on the surface of T cells following activation (peaking at 3 days) but is often present with the cytoplasm. CD152 is a ligand for CD80 and CD86 and is important in cellular interactions during the immune response.
Preparation:	Purified by affinity chromatography
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium Azide0. 5%Bovine Serum AlbuminSuggested
Flow Cytometry:	Membrane permeabilisation is required for this application. We recommend the use of Leucoperm for this purpose. Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10Immunohistology - Frozen - 5ug/ml 1. Linsley. P. S. et al. (1992) Co-expression and functional co-operation of CTLA-4 and CD28 on activated T lymphocytes. 2. Kuiper. H. M. et al. (1995) Activated T cells can induce high levels of CTLA-4 expression on B cells. 3. Castan. J. et al. (1997) Accumulation of CTLA-4 expressing T lymphocytes in the germinal centres of human lymphoid tissues.

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Amount: 0.2 mg

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Delivery expected until 8/30/2024