IFN GAMMA

IFN GAMMANCBI

IFN GAMMA

Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3X63-Ag-8. 653 myeloma cell line.

Purified IgG prepared by ion exchange chromatography

Flow Cytometry - Neat - 1/10 Summary: Interferon-gamma (IFNG) or type II interferon is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson 2007 [PubMed 17981204]). [supplied by OMIM]. 1. Andersson. U. et al. (1986) Phenotypic characterization of individual interferon gamma producing cells after OKT3 antibody activation. 2. Sandvig. S. et al. (1987) Gamma-interferon is produced by CD3+ and CD3- lymphocytes. 3. Andersson. U. et al. (1988) Enumeration of interferon gamma producing cells by