Item no. |
20-783-310108 |
Manufacturer |
GENWAY
|
Amount |
0.025 mg |
Category |
|
Type |
Antibody |
Applications |
FC, IP |
Clone |
LOB 3/11 |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GWB-D3B2C0 |
Similar products |
20-783-310108 |
Available |
|
Genway ID: |
GWB-D3B2C0 |
Specificity: |
CD95NCBI |
Gene ID: |
355 |
Isotype: |
IgG1 |
Clone: |
LOB 3/11 |
Immunogen: |
Fusion protein comprising extracellular domain of human Fas linked to human Fc |
Fusion Partner: |
Spleen cells from immunised BALB/c mice were fused with cells of the mouse NSI myeloma cell line. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein A |
Buffer Solution: |
Phosphate buffered saline |
|
Preservative Stabilisers: |
| 0. 09%Sodium AzideSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested |
Dilution: |
Flow Cytometry - 1/50 - 1/100Immunoprecipitation - 20ug/ml |
Function: |
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance in the antigen-stimulated suicide of mature T-cells or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
Subunit: |
Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. |
Subcellular Location: |
Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Subcellular Location: |
Isoform 2: Secreted. |
Subcellular Location: |
Isoform 3: Secreted. |
Subcellular Location: |
Isoform 4: Secreted. |
Subcellular Location: |
Isoform 5: Secreted. |
Subcellular Location: |
Isoform 6: Secreted. |
Tissue Specificity: |
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. |
Domain: |
Contains a death domain involved in the binding of FADD and maybe to other cytosolic adapter proteins. |
Disease: |
Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. |
Similarity: |
Contains 1 death domain. |
Similarity: |
Contains 3 TNFR-Cys repeats. |
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