TRPM4 Antibody

GWB-357B90

IgG1 Description: Homo sapiens transient receptor potential cation channel subfamily M member 4 (TRPM4)

WB 1:2000 Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+) it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)) leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes neurons from entorhinal cortex dorsal root and vomeronasal neurons endocrine pancreas cells kidney epithelial cells cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload