SLC7A8 Antibody

GWB-EACE04

IgG1 Description: Homo sapiens solute carrier family 7 (amino acid transporter L-type) member 8 (SLC7A8) transcript variant 1

WB 1:500; Flow 1:500 Sodium-independent high-affinity transport of small and large neutral amino acids such as alanine serine threonine cysteine phenylalanine tyrosine leucine arginine and tryptophan when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD L-homocysteine complexes and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.