Item no. |
20-511-240928 |
Manufacturer |
GENWAY
|
Amount |
1 mg |
Category |
|
Type |
Antibody |
Applications |
ELISA |
Clone |
100 |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
GWB-AF1FE9 |
Similar products |
20-511-240928 |
Available |
|
Genway ID: |
GWB-AF1FE9 |
Isotype: |
IgG2b |
Clone: |
100Host Animal: Mouse. Hybridization of Sp2/0 myeloma |
Clone: |
10E1 |
Type of Product: |
Monoclonal Antibodies to Hormones and Steroids |
Concentration: |
4. 8mg/ml (Sigma protein assay kit)Preservatives: 0. 1% sodium azide |
Buffer: |
PBS. pH 7. 4 Applications Notes : Detection of human PAPP-A antigen in immunoassay. Recommended pairs for sandwich immunoassay:Capture: 20-511-241013 Detection: 20-511-240928 |
Warning: |
This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PAPP-A. Monoclonal Antibody to Human Pregnancy Associated Plasma Protein A (PAPP-A) |
Function: |
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5 resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
Catalytic Activity: |
Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4 and the 143-Ser-|-Lys-144 bond in IGFBP-5. Cofactor: Binds 1 zinc ion per subunit (By similarity). |
Enzyme Regulation: |
Inhibited by complexation with the proform of PRG2. |
Subunit: |
Homodimer; disulfide-linked. In pregnancy serum predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2. |
Subcellular Location: |
Secreted. |
Tissue Specificity: |
High levels in placenta and pregnancy serum. In placenta expressed in X cells in septa and anchoring villi and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney myometrium endometrium ovaries breast prostate bone marrow colon fibroblasts and osteoblasts. Developmental Stage: Present in serum and placenta during pregnancy; levels increase throughout pregnancy. |
Induction: |
By 8-bromoadenosine-3\' 5\' -phosphate. |
Ptm: |
There appear to be no free sulfhydryl groups. |
Similarity: |
Belongs to the peptidase M43B family [view classification]. |
Similarity: |
Contains 5 Sushi (CCP/SCR) domains. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
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