Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
131-11912(19 |
Amount |
1mg |
Item no. |
20-511-240300 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
GWB-1380C2 |
Genway ID: |
GWB-1380C2 |
Isotype: |
IgM. k |
Clone: |
131-11912(19A2-17)Host Animal: Mouse |
Immunogen: |
Purified Proliferating Cell Nuclear Antigen |
Specificity: |
PCNA (Proliferating Cell Nuclear Antigen). formerly called Cyclin. is a 36 kD proliferation associated antigen. |
Type of Product: |
Monoclonal Antibodies to Apoptosis and Signal Transduction Reagents |
Concentration: |
Not determinedPreservatives: NaN3 |
Buffer: |
Not applicableApplications Notes : Specific methodologies have not been tested using this product. |
Warning: |
This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. MAb to PCNA. Monoclonal Antibody to Proliferating Cell Nuclear Antigen (PCNA) |
Function: |
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase\' s processibility during elongation of the leading strand. |
Subunit: |
Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH POLK DNMT1 ERCC5/XPG FEN1 CDC6 APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1 POLD3 and POLD4. |
Subcellular Location: |
Nucleus. |
Ptm: |
Upon methyl methanesulfonate-induced DNA damage mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through \' Lys-63\' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH whih is required for DNA repair. |
Disease: |
Antibodies are present in sera from patients with systemic lupus erythematosus. |
Similarity: |
Belongs to the PCNA family. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.