SRY (sex determining region Y)-box 6 (SOX6)

GWB-5C48AA

Binds specifically to the DNA sequence 5\' -AACAAT-3\' .

Nucleus (Potential).

Contains 1 HMG box DNA-binding domain. Summary: The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors SOX transcription factors bind to the minor groove of DNA causing a 70- to 85-degree bend and introducing local conformational changes. [supplied by OMIM]. [1] Ikeda T. Saito T. Ushita M. Yano F. Kan A. Itaka K. Moro T. Nakamura K. Kawaguchi H. and Chung U. I. Identification and characterization of the human SOX6 promoter[2] Fernandez-Lloris R. Osses N. Jaffray E. Shen L. N. Vaughan O. A. Girwood D. Bartrons R. Rosa J. L. Hay R. T. and Ventura F. Repression of SOX6 transcriptional activity by SUMO modification[3] Mehrle A. Rosenfelder H. Schupp I. del Val C. Arlt D. Hahne F. Bechtel S. Simpson J. Hofmann O. Hide W. et al. The LIFEdb database in 2006[4] Ueda R. Yoshida K. Kawakami Y. Kawase T. and Toda M. et al. Immunohistochemical analysis of SOX6 expression in human brain tumors[5] Ueda R. Yoshida K. Kawakami Y. Kawase T. and Toda M. et al. Expression of a transcriptional factor SOX6 in human gliomas[6] Cohen-Barak O. Hagiwara N. Arlt M. F. Horton J. P. Brilliant M. H. Cloning characterization and chromosome mapping of the human SOX6 gene. [7] Wiemann S. Weil B. Wellenreuther R. Gassenhuber J. Glassl S. Ansorge W. Boecher M. Bloecker H. Bauersachs S. Blum H. et al. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. [8] Denny P. Swift S. Brand N. Dabhade N. Barton P. Ashworth A. A conserved family of genes related to the testis determining gene SRY.