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Jab1 [6C3.38]

Jab1 [6C3.38]

Item no.	20-272-193297
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Immunoprecipitation Western Blot Primary Antibodies By Organ Bladder Cancer
Type	Antibody
Applications	WB, IP
Clone	6C3. 38
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3675FA
Similar products	20-272-193297
Available
Genway ID:	GWB-3675FA
Clone:	6C3. 38
Isotype:	IgG2aLight chain: kappa
Immunogen:	The full-length mouse JAB-1 gene expressed in E. coli.
Antigen Species:	Mouse
Positive Control:	293 cell lysate
Target:	Jab1
Localization:	Nuclear/Cytoplasmic
Concentration:	1 mg/ml
Purification Note:	From hybridoma tissue culture supernatant Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	For IP: Use at a concentration of 0. 5 - 1 ug/ml. For WB: Use at a concentration of 0. 5-1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein
Molecular Weight:	38 Cellular
Localization:	Nuclear/Cytoplasmic Expression system: pGEX Myeloma: NS1 JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the \" \" Signalosome\" \" which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear it has recently been implicated in targeting proteins for degradation by the proteasome.
Function:	Probable protease subunit of the COP9 signalosome complex (CSN) a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53 c-jun/JUN IkappaBalpha/NFKBIA ITPK1 and ICSBP possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system respectively. In the complex it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts direclty with a large number of proteins that are regulated by the CSN complex confirming a key role in the complex. Cofactor: Divalent metal ions (By similarity).
Subunit:	Component of the CSN complex composed of COPS1/GPS1 COPS2 COPS3 COPS4 COPS5 COP6 COPS7 (COPS7A or COPS7B) and COPS8. In the complex it probably interacts directly with COPS1 COPS2 COPS4 COPS6 and COPS7 (COPS7A or COPS7B). Also exists as monomeric form. Interacts with TP53 MIF JUN UCHL1 NCOA1 HIF1A CDKN1B BCL3 GFER PGR LHCGR SMAD4 SMAD7 ID1 ID3 ITGB2 and TOP2A. Part of a complex consisting of RANBP9 Ran DYRK1B and COPS5.
Subcellular Location:	Cytoplasm. Nucleus.
Domain:	The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It may constitute the catalytic center of the complex (By similarity).
Similarity:	Belongs to the peptidase M67A family. CSN5 subfamily [view classification].
Similarity:	Contains 1 MPN (JAB/Mov34) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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