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Ferritin [057-10030]

Ferritin [057-10030]

Item no.	20-272-193212
Manufacturer	GENWAY
Amount	0.1 mg
Category	Antibodies ELISA Primary Antibodies
Type	Antibody
Applications	ELISA
Clone	057-10030
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-7DC355
Similar products	20-272-193212
Available
Genway ID:	GWB-7DC355
Clone:	057-10030
Isotype:	IgG1Light chain: kappa
Immunogen:	Ferritin isolated from human liver.
Antigen Species:	Human
Specificity:	This antibody is specific to Ferritin.
Target:	Ferritin
Localization:	Cytoplasmic/Mitochondrial
Concentration:	5. 2 mg/ml
Purification Note:	This antibody is > 90% pure (SDS PAGE). It was purified from ascites by protein A chromatography and is 0. 2um filtered. Storage
Preservative:	0. 1% Sodium Azide. Constituents: 150mM Sodium chloride 10mM Phosphate. pH 7. 4.
Application Note:	ELISA: Use at an assay dependent dilution. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic/Mitochondrial Ferritin is the major intracellular iron storage protein in all organisms. It has the shape of a hollow sphere that permits entry of a variable amount of iron for storage as ferric hydroxide phosphate complexes. Mammalian liver and spleen ferritin (relative mass about 450 000) consists of 24 subunits of 2 species the heavy subunit (relative mass = 21 000) and the light subunit (relative mass = 19 000). If aliquoted for long term storage the antibody fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used.
Function:	Stores iron in a soluble non-toxic readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Subunit:	Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Disease:	Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.
Disease:	Defects in FTL are the cause of neuroferritinopathy [MIM:606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism ataxia corticospinal signs mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.
Similarity:	Belongs to the ferritin family.
Similarity:	Contains 1 ferritin-like diiron domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/13/2024

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