« Back
Home /
Trypsin [401]

Trypsin [401]

Manufacturer	GENWAY
Category	Oncology Antibodies Primary Antibodies By Organ Pancreatic Cancer
Type	Antibody
Specific against	other
Clone	401
Amount	0.1 mg
Item no.	20-272-193106
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	GWB-598B45
Genway ID:	GWB-598B45
Clone:	401
Isotype:	IgG2b
Immunogen:	Full length native protein (purified) (Human pancreatic).
Antigen Species:	Human
Specificity:	This product does not cross-react with pancreatic chymotrypsin.
Target:	Trypsin
Localization:	Secreted
Concentration:	1. 1 mg/ml
Purification Note:	From mouse ascitic fluid. Storage
Buffer:	Phosphate-buffered saline pH 7. 4 containing no preservatives
Application Note:	IA: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Secreted Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor trypsinogen but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screen for and diagnose Cystic Fibrosis.
Function:	Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec Boc-Leu-Thr-Arg-Mec Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Catalytic Activity:	Preferential cleavage: Arg-\|-Xaa Lys-\|-Xaa. Cofactor: Binds 1 calcium ion per subunit.
Subcellular Location:	Secreted extracellular space.
Ptm:	Occurs in a single-chain form and a two-chain form produced by proteolytic cleavage after Arg-122. Mass Spectrometry: Mass=24348; Mass_error=2; Method=Electrospray; Range=24-247; Source=PubMed:8683601; .
Disease:	Defects in PRSS1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.
Similarity:	Belongs to the peptidase S1 family [view classification].
Similarity:	Contains 1 peptidase S1 domain [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.1 mg

available

Delivery expected until 7/26/2024