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Synaptophysin [SYP02]

Synaptophysin [SYP02]

Item no.	20-272-192643
Manufacturer	GENWAY
Amount	0.5 ml
Category	Oncology Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Blastoma Immunohistochemistry Primary Antibodies By Organ Lung Cancer
Type	Antibody
Applications	IHC
Clone	SYP02
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-CC0680
Similar products	20-272-192643
Available
Genway ID:	GWB-CC0680
Clone:	SYP02
Isotype:	IgG1
Immunogen:	BALB/C mice were injected with a synthetic peptide encoding a region near the c-terminal end of the synaptophysin protein.
Antigen Species:	Mouse
Specificity:	This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types. This antibody is specific to a 38 kD protein.
Positive Control:	Pancreas
Target:	Synaptophysin
Localization:	Integral membrane protein. Synaptic vesicles.
Concentration:	tissue culture supernatant Storage
Buffer:	Tissue culture supernatant containing 0. 09% sodium azide
Application Note:	This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However depending on the staining conditions employed we suggest that final dilution should be determined by the user. Cellular
Localization:	Integral membrane protein. Synaptic vesicles. Synaptophysin is a 38kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain spinal cord retina vesicles of adrenal medulla neuromuscular junctions and endocrine cells. It is also expressed by neuroendocrine cells throughout the body both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla carotid body skin pituitary gland thyroid lung pancreas and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas ganglioneuroblastomas ganglioneuromas pheochromocytomas chromaffin and non-chromaffin paragangliomas.
Function:	Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
Subunit:	Homohexamer or homotetramer.
Subcellular Location:	Cytoplasmic vesicle secretory vesicle synaptic vesicle membrane; Multi-pass membrane protein. Cell junction synapse synaptosome.
Tissue Specificity:	Characteristic of a type of small (30-80 nm) neurosecretory vesicles including presynaptic vesicles but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
Domain:	The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
Ptm:	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).
Similarity:	Belongs to the synaptophysin/synaptobrevin family.
Similarity:	Contains 1 MARVEL domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 ml

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