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CD147 [MEM-M6/1]

CD147 [MEM-M6/1]

Item no.	20-272-192051
Manufacturer	GENWAY
Amount	0.1 mg
Category	Antibodies Immunoprecipitation Western Blot Primary Antibodies
Type	Antibody
Applications	WB, IP
Clone	MEM-M6/1
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-7DFA5B
Similar products	20-272-192051
Available
Genway ID:	GWB-7DFA5B
Clone:	MEM-M6/1
Isotype:	IgG1
Immunogen:	Protein A-CR purified soluble recombinant form of CD147 CD147Rg which consists of the cDNA coding for the hinge region CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).
Antigen Species:	Human
Specificity:	Human CD147 antigen. This antibody recognizes an epitope in the N-terminal Ig domain (D1). This high-affinity antibody is capable of binding to unstimulated peripheral blood T cells.
Target:	CD147
Concentration:	1 mg/ml
Purification Note:	Purified from ascites by protein A-affinity chromatography. Storage
Buffer:	Phosphate buffered saline pH 7. 4 containing 15mM sodium azide
Application Note:	FACS: Use at an assay dependant concentration. IP: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Use under non-reducing conditions. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Function:	Plays pivotal roles in spermatogenesis embryo implantation neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1 SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro promotes outgrowth of astrocytic processes (By similarity).
Subunit:	Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2 MAG and L1CAM (By similarity). Interacts with AJAP1.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity:	Present only in vascular endothelium in non-neoplastic regions of the brain whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Induction:	Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
Ptm:	N-glycosylated.
Similarity:	Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Similarity:	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 8/30/2024

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