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PKC [MC5]

PKC [MC5]

Item no.	20-272-191965
Manufacturer	GENWAY
Amount	0.1 mg
Category	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Immunocytochemistry Immunoassay Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Applications	WB, IF, IP, IHC, ICC, ELISA, RIA
Clone	MC5
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-29ED23
Similar products	20-272-191965
Available
Genway ID:	GWB-29ED23
Clone:	MC5
Isotype:	IgG2a
Immunogen:	Purified bovine brain protein kinase C
Antigen Species:	Bovine
Target:	PKC
Localization:	Cytoplasmic and membrane associated
Concentration:	2. 7 mg/ml Storage
Buffer:	Phosphate-buffered saline
Application Note:	Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cytoplasmic and membrane associated Myeloma: P3x63 Use: It should be possible to selectively block degradation of PKC without affecting the membrane-associated activation. This will allow an assessment of the role of proteolysis in the activation of the protein kinase pathway.
Function:	This is a calcium-activated phospholipid-dependent serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4.
Function:	PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters a class of tumor promoters.
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein. Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
Subunit:	Interacts with CENTA1 CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine.
Similarity:	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:	Contains 1 AGC-kinase C-terminal domain.
Similarity:	Contains 1 C2 domain.
Similarity:	Contains 2 phorbol-ester/DAG-type zinc fingers.
Similarity:	Contains 1 protein kinase domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/27/2024

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