Tau Phospho (pS721)

GWB-9AF756

A phospho-specific peptide corresponding to residues surrounding Serine 721 of human Tau was used as an immunogen.

WB: 1:1 000 - 2 000IHC: 1:100 - 250. Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1 2). Tau is hyperphosphorylated in PHFs and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state including Ser 199/202 Thr 231 and Ser 393/404 (3). Glycogen synthase kinase-3 or GSK-3 phosphorylates Tau on Ser 396 (4). 1. Goedert M. et al. Proc Natl Acad Sci U S A. 85: 40512. Jakes R. et al. EMBO J. 10: 27253. Maas T. et al. J Bi2. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487