TPPP

Item no.	20-203-421158
Manufacturer	GENWAY
Amount	0,1 ml
Category	Antibodies Flow Cytometry Immunohistochemistry Western Blot Immunocytochemistry Primary Antibodies
Type	Antibody
Applications	WB, FC, IHC, ICC
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-6ABC8D
Similar products	20-203-421158
Available
Genway ID:	GWB-6ABC8D
Clone ID:	EPR3316
Immunogen:	A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.
Specificity:	A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.
Dilution:	WB: 1:500 - 1000IHC: 1:250 - 500ICC: 1:100 - 250FC: 1:50. Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA) a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP) and has been shown to colocalize with MBP in myelin in normal human brains (2). 1. Hlavanda E et al. J Biol Chem. 282(40):29531-9 20072. Song YJ et al. Am J Pathol. 171(4):1291-303 20073. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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