LRP6 Phospho (pS1490)

GWB-BFE10E

A phospho specific peptide corresponding to residues surrounding serine 1490 of human LRP6 was used as an immunogen. This antibody detects LRP6 phosphorylated on serine 1490.

WB: 1:500 - 1000ICC: 1:100 - 250. LRP6 (low-density lipoprotein receptor-related protein 6) is a single span transmembrane Wnt receptor that interacts with Axin to promote the Wnt-dependent accumulation of beta-catenin. Cells treated with Wnt quickly induce plasma membrane-associated LRP6 aggregates. The aggregates are phosphorylated and then promote Axin recruitment and beta-catenin stabilization. LRP6 is internalized with caveolin and components of this endocytic pathway are required not only for Wnt-3a-induced internalization of LRP6 but also for accumulation of beta-catenin. Wnt-3a triggers the interaction of LRP6 with caveolin and promotes recruitment of Axin to LRP6 phosphorylated at Serine 1490 by glycogen synthase kinase-3beta (1-2). 1. Bilic J et al. Science 316(5831):1619-22 20072. Yamamoto H et al. Cell 11(2):213-23 20063. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487