JAM1 (N-Term)

GWB-E91E8E

A synthetic peptide corresponding to residues near the N-terminus of human JAM1 was used as an immunogen.

WB: 1:2000IHC: 1:100 - 250. Junctional Adhesion Molecules (JAMs) are components and regulators of the well-characterized epithelial and endothelial tight junction. JAM is selectively concentrated at intercellular junctions of endothelial and epithelial cells of different origins. Microscopy shows that JAM codistributes with tight junction components at the apical region of the intercellular cleft. A mAb directed to JAM (BV11) was found to inhibit spontaneous and chemokine-induced monocyte transmigration through an endothelial cell monolayer in vitro. Systemic treatment of mice with BV11 mAb blocked monocyte infiltration upon chemokine administration in subcutaneous air pouches (1). The human protein shares a highly conserved structure and sequence with the murine protein. However it is distinct in that it is constitutively expressed on circulating neutrophils monocytes platelets and lymphocyte subsets (2). 1. Martin-Padura I et al. J Cell Biol 142(1):117-27 19982. Williams LA et al. Mol Immunol 36(17):1175-88. 3. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487