Hsp60

GWB-62B2C4

A synthetic peptide corresponding to residues in the internal region of human Hsp60 was used as an immunogen.

WB: 1:5000IHC: 1:100-250. The 60-kDa Heat Shock Protein (Hsp60) is a highly conserved member of the molecular chaperone network commonly imported into the mitochondria to assist in the folding and assembly of mitochondrial proteins (1). Under environmental stress conditions synthesis of Hsp60 is up-regulated then involved in gene expression regulation DNA replication signal transduction differentiation apoptosis cellular senescence or immortalization (2). Hsp60 is also believed to protect mitochondrial ATPase activity under conditions of increasing temperature (3). Hsp60 along with Hsp70 has also been shown to play a role in a danger signalling cascade in response to bacterial infection (4). 1. Prasad YM et al. Mol Cell Biol (8):3979-86 19902. Czarnecka AM et al. Cancer Biol Ther. (7):714-20 20063. Patriarca EJ Exp Cell Res. (1):57-64 19904. Davies EL et al. Clin Exp Immunol. (1):183-9 20065. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487