MALT1/MLT1 (N-term)

GWB-5FDF00

A synthetic peptide corresponding to residues in the N-term of human MALT1 was used as immunogen. This antibody is predicted to detect splice isoform 2 based on sequence analysis.

WB: 1:500 - 2 000FC: 1:30IP: 1:50. Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) also known as MLT1 or paracaspase 1 is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro In vitro MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5). 1. Hoshi N Kusakabe T Taylor BJ et al Side population cells in the mouse thyroid exhibit stem/progenitor celllike characteristics Endocrinology 148 (2007) 4251 - 4258[Application: ICC]2. Birle DC and Hedley DW Signaling interactions of rapamycin combined with erlotinib in cervical carcinoma xenografts Mol Cancer Ther 5 (2006) 2494-2502[Application: WB]3. McCully RR and Pomerantz JL The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF- B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association Molecular and Cellular Biology 28 (2008) 5668-5686[Application: WB]1. Uren AG O\' Rourke K Aravind LA et al. Mol Cell. 2000; 6: 961-9672. Lucas PC Yonezumi M Inohara N et al. J Biol Chem. 2001; 276: 19012-19019. 3. Zhou H Wertz I O\' Rourke K et al. Nature. 2004; 427: 167-171. 4. Dierlamm et al. ; Blood 1999 93:3601-36095. Akagi et al. Oncogene 1999 18:5785-57946. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487