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Anti-TNFÎ±

Anti-TNFÎ±

Item no.	20-003-40016
Manufacturer	GENWAY
Amount	0,2 mg
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3F7751
Similar products	20-003-40016
Available
Genway ID:	GWB-3F7751
Clone Number:	3D12
Antigen Specificity:	Mouse monoclonal antibody (3D12) was raised against a recombinant TNF& alpha; fusion protein.
Category:	Tumor Suppressor Genes & Apoptosis
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. TNF-alpha is a member of a family of cytokines. All known members of the TNF-alpha cytokine family induce hepatic expression of acute phase proteins . Monocytes express at least five different molecular forms of TNF-alpha with molecular masses of 21. 5-28
Function:	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Subunit:	Homotrimer.
Subcellular Location:	Cell membrane; Single-pass type II membrane protein.
Subcellular Location:	Tumor necrosis factor soluble form: Secreted.
Ptm:	The soluble form derives from the membrane form by proteolytic processing.
Ptm:	The membrane form but not the soluble form is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
Similarity:	Belongs to the tumor necrosis factor family. Jelinkova. L. . et al. . 2004. FEBS Lett. 571(1-3). 81-5; .

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,2 mg

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Delivery expected until 9/27/2024