BMP-2

BMP-2NCBI

BMP-2

Antisera to human BMP-2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified by affinity chromatography.

ELISA - 0. 25 ug/ml - 1. 0 ug/mlWestern Blotting - 0. 1 ug/ml - 0. 2 ug/ml Summary: This protein is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. 1. Balemans. W. and Van Hul. W. (2002) Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. 2. Sebald. W. et al. (2004) Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. 3. Keller. S. et al. (2004) Molecular recognition of BMP-2 and BMP receptor IA. 4. Kirsch. T. et al. (2000) BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. 5. Kimura. N. et al. (2000) BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6.