IL-17

IL-17NCBI

Polyclonal IgG

This product is specific for human IL-17 (Interleukin-17/17A) a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains which belongs to the IL-17 family (classified as IL-17A to IL-17F) and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines including IL-1beta IL-6 TNFalpha IFNgamma and granulocyte colony-stimulating factor as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis in which levels of IL-17 are significantly increased and may contribute to bone destruction.

Phosphate buffered saline

For functional studies do not use Azide. Suggested

ELISA - 0. 5-2. 0 ug/mlWestern Blotting - 0. 1 - 0. 2ug/mlFunctional Assays - 0. 93 - 1. 3 ug/ml Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2) as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis psoriasis and multiple sclerosis. Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2) as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis psoriasis and multiple sclerosis. [provided by RefSeq]. 1. Gaffen. S. L. (2004) Biology of recently discovered cytokines; Interleukin-17 a unique inflammatory cytokine with roles in bone biology and arthritis. Arth. Res. and Therapy. 6: 240-247.