RABBIT ANTI CDNF (C-TERMINAL)

GWB-BCED34

Polyclonal IgGSpecies Cross Reactivity: Reacts with: Mouse RatN. B. Antibody reactivity and working conditions may vary between species.

Recognises human conserved dopamine neurotrophic factor (CDNF) a 20. 9 kDa secreted protein belonging to the ARMET family. CDNF is a neutrophic factor for dopaminergic neurons. Studies have demonstrated that CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson\' s disease. Additionally CDNF has been shown to restore the dopaminergic function and prevent the degeneration of dopaminergic neurones in the substantia nigra suggesting that CDNF may have potential in the treatment of Parkinson\' s disease. CDNF exists in at least two known isoforms and is widely expressed in both neuronal and non-neuronal tissues. Within the brain highest expression is observed in the optic nerve and corpus callosum.

Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra By similarity. Subcellular locationSecretedRef. 4Ref. 5. Tissue specificityWidely expressed in neuronal and non-neuronal tissues. In the brain highest levels in the optic nerve and corpus callosum. Ref. 4Induction: Not induced by endoplasmic reticulum (ER) stress. Ref. 5Sequence similaritiesBelongs to the ARMET family. 1. Denning S. M. et al. (1995) AS10 CD44 and CD45R Cluster report. In Leucocyte Typing V. White cell differentiation antigens. Eds Schlossman S. F. et al. Oxford University Press. Volume 2:1713 - 1719 [1] \" A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. \" Stamenkovic I. Amiot M. Pesando J. M. Seed B. Cell 56:1057-1062(1989) [PubMed: 2466575] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). [2] \" The multispecific cell adhesion molecule CD44 is represented in reticulocyte cDNA. \" Harn H. -J. Isola N. Cooper D. L. Biochem. Biophys. Res. Commun. 178:1127-1134(1991) [PubMed: 1840487] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). Tissue: Reticulocyte. [3] \" The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. \" Stamenkovic I. Aruffo A. Amiot M. Seed B. EMBO J. 10:343-348(1991) [PubMed: 1991450] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10). [4] \" Molecular cloning of CD44R1 and CD44R2 two novel isoforms of the human CD44 lymphocyte \' homing\' receptor expressed by hemopoietic cells. \" Dougherty G. J. Lansdorp P. M. Cooper D. L. Humphries R. K. J. Exp. Med. 174:1-5(1991) [PubMed: 2056274] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11). Tissue: Myeloid leukemia cell. [5] \" The core protein of epican a heparan sulfate proteoglycan on keratinocytes is an alternative form of CD44. \" Kugelman L. C. Ganguly S. Haggerty J. G. Weissman S. M. Milstone L. M. J. Invest. Dermatol. 99:886-891(1992) [PubMed: 1281868] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4) VARIANT LYS-417. Tissue: Keratinocyte. [6] \" Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. \" Screaton G. R. Bell M. V. Jackson D. G. Cornelis F. B. Gerth U. Bell J. I. Proc. Natl. Acad. Sci. U. S. A. 89:12160-12164(1992) [PubMed: 1465456] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] ALTERNATIVE SPLICING. Tissue: Lymphoblast. [7] \" CD44: a multitude of isoforms with diverse functions. \" Gunthert U. Curr. Top. Microbiol. Immunol. 184:47-63(1993) [PubMed: 7508842] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT HIS-494. [8] \" Novel variants of CD44 arising from alternative splicing: changes in the CD44 alternative splicing pattern of MCF-7 breast carcinoma cells treated with hyaluronidase. \" Tanabe K. K. Nishi T. Saya H. Mol. Carcinog. 7:212-220(1993) [PubMed: 8352881] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 13 AND 14). Tissue: Mammary carcinoma. [9] \" CD44 in normal and neoplastic human cartilage. \" Bosch P. P. Stevens J. W. Buckwalter J. A. Midura R. J. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12). Tissue: Articular cartilage. [10] \" Sequence analysis of the human CD44 antigen. \" Wiebe G. J. Freund D. Corbeil D. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 12). Tissue: Colon adenocarcinoma and Retinal pigment epithelium.