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Rabbit anti TNFRSF14 (CT)

Rabbit anti TNFRSF14 (CT)

Manufacturer	GENWAY
Category	Oncology Antibodies Western Blot Primary Antibodies By Organ Lung Cancer
Type	Antibody
Specific against	other
Applications	WB
Amount	0,1 mg
Host	Rabbit
Item no.	18-511-244446
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	GWB-CD5887
Genway ID:	GWB-CD5887
Host Animal:	Rabbit
Immunogen:	Synthetic peptide corresponding to 16 amino acids near the carboxy terminal of human TNFRSF14 (Genbank accession No. Q92956)
Specificity:	Tumor Necrosis Factor Receptor Superfamily 14 (TNFRSF14) C-terminal
Specificity:	Reacts with human TNFRSF14. TNFRSF14 was initially identified as the Herpesvirus entry mediator (2) and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT alpha) activates the transcription factors NF-kappaB and AP-1 (3 4). Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production leading to inflammation and enhanced CTL-mediated tumor immunity.
Type of Product:	Polyclonal Antibodies to Apoptosis and Signal Transduction Reagents
Concentration:	Lot specificPreservatives: NaN3
Buffer:	PBSApplications Notes : Suitable for use in Western blot (1?2ug/ml). Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Warning:	This product contains sodium azide which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0. 1â ??1. 0%. When disposing of this reagent through lead or copper plumbing flush with copious volumes of water to prevent azide build-up in drains. Rabbit anti TNFRSF14 (CT). Rabbit Antibody to Human Tumor Necrosis Factor Receptor Superfamily 14 (TNFRSF14) C-terminal
Function:	Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells and mediated HSV entry into activated human T-cells.
Subunit:	Interacts with TRAF2 TRAF3 and TRAF5.
Subcellular Location:	Membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:	Widely expressed with the highest expression in lung spleen and thymus.
Ptm:	N-glycosylated.
Similarity:	Contains 3 TNFR-Cys repeats.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,1 mg

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Delivery expected until 7/26/2024

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