Brain-specific angiogenesis inhibitor 1

GWB-80A51E

Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.

Cell membrane; multi-pass membrane protein. Likely to be concentrated at cell-cell adhesion sites.

By p53.

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].

Contains 5 TSP type-1 domains. Summary: Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one \' functional\' p53-binding site within an intron and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family an inhibitor of angiogenesis and a growth suppressor of glioblastomas. [1] Bjarnadottir T. K. Fredriksson R. Hoglund P. J. Gloriam D. E. Lagerstrom M. C. and Schioth H. B. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors[2] Koh J. T. Kook H. Kee H. J. Seo Y. W. Jeong B. C. Lee J. H. Kim M. Y. Yoon K. C. Jung S. and Kim K. K. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin[3] Kaur B. Brat D. J. Calkins C. C. and Van Meir E. G. et al. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression[4] Lim I. A. Hall D. D. and Hell J. W. et al. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102[5] Mori K. Kanemura Y. Fujikawa H. Nakano A. Ikemoto H. Ozaki I. Matsumoto T. Tamura K. Yokota M. and Arita N. Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells[6] Nishimori H. Shiratsuchi T. Urano T. Kimura Y. Kiyono K. Tatsumi K. Yoshida S. Ono M. Kuwano M. Nakamura Y. et al. A novel brain-specific p53-target gene BAI1 containing thrombospondin type 1 repeats inhibits experimental angiogenesis. [7] Shiratsuchi T. Futamura M. Oda K. Nishimori H. Nakamura Y. Tokino T. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. [8] Oda K. Shiratsuchi T. Nishimori H. Inazawa J. Yoshikawa H. Taketani Y. Nakamura Y. Tokino T. Identification of BAIAP2 (BAI-associated protein 2) a novel human homologue of hamster IRSp53 whose SH3 domain interacts with the cytoplasmic domain of BAI1.