B1 bradykinin receptor

GWB-9D8DC6

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Belongs to the G-protein coupled receptor 1 family [view classification]. Summary: Bradykinin a 9 aa peptide is generated in pathophysiologic conditions such as inflammation trauma burns shock and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration ultimately resulting in chronic and acute inflammatory responses. [1] Stadnicki A. Pastucha E. Nowaczyk G. Mazurek U. Plewka D. Machnik G. Wilczok T. and Colman R. W. Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease[2] Angers M. Drouin R. Bachvarova M. Paradis I. Bissell B. Hiromura M. Usheva A. and Bachvarov D. In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor (BDKRB1) gene promoter: evidence for cell-specific regulation[3] Feng D. M. Wai J. M. Kuduk S. D. Ng C. Murphy K. L. Ransom R. W. Reiss D. Chang R. S. Harrell C. M. MacNeil T. Tang C. et al. 2 3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists[4] Prat A. Biernacki K. Saroli T. Orav J. E. Guttmann C. R. Weiner H. L. Khoury S. J. and Antel J. P. Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability[5] Liesmaa I. Kuoppala A. Shiota N. Kokkonen J. O. Kostner K. Mayranpaa M. Kovanen P. T. and Lindstedt K. A. Increased expression of bradykinin type-1 receptors in endothelium of intramyocardial coronary vessels in human failing hearts[6] Menke J. G. Borkowski J. A. Bierilo K. K. Macneil T. Derrick A. W. Schneck K. A. Ransom R. W. Strader C. D. Linemeyer D. L. Hess J. F. et al. Expression cloning of a human B1 bradykinin receptor. [7] Yang X. Polgar P. Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. [8] Bachvarov D. R. Hess J. F. Menke J. G. Larrivee J. F. Marceau F. Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). [9] Jones C. Phillips E. Davis C. Arbuckle J. Yaqoob M. Burgess G. M. Docherty R. J. Webb M. Bevan S. J. McIntyre P. et al. Molecular characterisation of cloned bradykinin B1 receptors from rat and human. [10] Suwa M. Sato T. Okouchi I. Arita M. Futami K. Matsumoto S. Tsutsumi S. Aburatani H. Asai K. Akiyama Y. et al. Genome-wide discovery and analysis of human seven transmembrane helix receptor genes.