Orphan nuclear receptor NR1D1

Internal domain of human. Synthetic peptide - KLH conjugated.
Uses: IHC (3 - 4 ug/ml) (Optimal dilution to be determined by the researcher)

Nucleus (Potential).

Composed of three domains: a modulating N-terminal domain a DNA-binding domain and a C-terminal steroid-binding domain.

Contains 1 nuclear receptor DNA-binding domain. [1] Yin L. Wang J. Klein P. S. and Lazar M. A. et al. Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock[2] Yin L. and Lazar M. A. et al. The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene[3] Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. and Gygi S. P. Large-scale characterization of HeLa cell nuclear phosphoproteins[4] Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. and Gygi S. P. Large-scale characterization of HeLa cell nuclear phosphoproteins[5] Migita H. Morser J. and Kawai K. et al. Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells[6] Miyajima N. Horiuchi R. Shibuya Y. Fukushige S. Matsubara K. Toyoshima K. Yamamoto T. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. [7] Lazar M. A. Jones K. E. Chin W. W. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. [8] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences. [9] Laudet V. Begue A. Henry C. Joubel A. Martin P. Stehelin D. Saule S. Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene. [10] Beausoleil S. A. Jedrychowski M. Schwartz D. Elias J. E. Villen J. Li J. Cohn M. A. Cantley L. C. Gygi S. P. Large-scale characterization of HeLa cell nuclear phosphoproteins.