Nuclear receptor ROR-gamma

Ligand-binding domain of human. Synthetic peptide - KLH conjugated.

Orphan nuclear receptor.

Highly expressed in skeletal muscle.

Contains 1 nuclear receptor DNA-binding domain. Summary: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [1] Wang H. Chu W. Das S. K. Zheng Z. Hasstedt S. J. and Elbein S. C. et al. Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes[2] Winoto A. and Littman D. R. et al. Nuclear hormone receptors in T lymphocytes[3] Kurebayashi S. Ueda E. Sakaue M. Patel D. D. Medvedev A. Zhang F. and Jetten A. M. Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis[4] Sun Z. Unutmaz D. Zou Y. R. Sunshine M. J. Pierani A. Brenner-Morton S. Mebius R. E. and Littman D. R. Requirement for RORgamma in thymocyte survival and lymphoid organ development[5] Villey I. de Chasseval R. and de Villartay J. P. et al. RORgammaT a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter[6] Hirose T. Smith R. J. Jetten A. M. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. [7] Strausberg R. L. Feingold E. A. Grouse L. H. Derge J. G. Klausner R. D. Collins F. S. Wagner L. Shenmen C. M. Schuler G. D. Altschul S. F. et al. Generation and initial analysis of more than 15 000 full-length human and mouse cDNA sequences.