TFF1

IgG

This antibody is specific to pS2 protein also known as pNR-2.

TFF1

serum with 0. 05% sodium azide

Secreted This antigen was identified by differential screening of cDNA libraries from estrogen responsive breast cancer cell lines. This antigen is expressed in normal gastric and small intestinal mucosa and breast epithelium. In cancer this antigen is expressed in gastric carcinoma and gynecological cancers. This antibody recognizes cytoplasm with perinuclear condensation. Presence of this antigen in breast carcinomas provides research investigators supplementary information for identifying patients with likely positive response to hormone therapy and a favorable prognosis.

Heterodimer with GKN2; disulfide linked.

Found in stomach with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum small submucosal glands in the esophagus mucous acini of the sublingual gland submucosal glands of the trachea and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract but lower expression found in gastric cancer (at protein level).

Contains 1 P-type (trefoil) domain.