Myoglobin (ready-to-use)

IgG

Human

MyoglobinConjugation

0. 083 mg/ml Storage

This antibody has been pretitered and quality controlled to work allon formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections. No further titration is required. We suggest an incubation period of 30-60 minutes at room temperature. However depending upon the fixation conditions and the staining system employed optimal incubation conditions should be determined by the user. Myoglobin is a small heme-containing protein (153 amino acid residues molecular weight (w/o heme) 17053 Da and theoretical pI=7. 29) responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient\' s blood 1-3 hours after onset of the symptoms reaching peak level within 8-12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.

Belongs to the globin family.