STAT5 phospho Y694

GWB-EB0FA5

Synthetic peptide (Human).

This product recognises phosphorylated STAT5.

STAT5

Purified from rabbit serum by sequential epitope-specific chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated STAT5. The final product is generated by affinity chromatography using a STAT5-derived peptide that is phosphorylated at tyrosine 694. Storage

WB: Use at a dilution of 1/1000. Detects a band of approximately 95 kDa (predicted

Nuclear STAT5a and STAT5b knockout mice show important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism respectively. Abnormal activity of certain STAT family members particularly STAT3 and STAT5 is associated with a wide variety of human malignancies including hematologic breast head and neck and prostate cancers. STAT5A and STAT6 are selectively activated when the heart is subjected to ischemic injury whereas activation of STAT3 and STAT5A is involved in myocardial hypertrophy. STAT5 and STAT3 as these two STAT molecules are required for normal breast development and involution respectively and may play an important role in breast carcinogenesis. The activation of STAT5 proteins (STAT5a and STAT5b) is one of the earliest signaling events mediated by IL 2 family cytokines.

signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Belongs to the transcription factor STAT family.