ADAM8

Item no.	18-272-195428
Manufacturer	GENWAY
Amount	0,05 mg
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-5FBEF6
Similar products	18-272-195428
Available
Genway ID:	GWB-5FBEF6
Isotype:	IgG
Immunogen:	Synthetic peptide (Human) corresponding to the amino terminal end of the catalytic domain.
Antigen Species:	Human
Specificity:	Does not react with other ADAMs.
Target:	ADAM8
Localization:	Cell Membrane
Concentration:	1 mg/ml Storage
Preservative:	0. 05% Sodium Azide; Constituents: 50% Glycerol PBS
Application Note:	WB: Use at a dilution of 1/1000. Detects bands of approximately 75 kDa and 60 kDa (in reduced sample). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:	Cell Membrane Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.
Function:	Possible involvement in extravasation of leukocytes. Cofactor: Binds 1 zinc ion per subunit (Probable).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Expressed on neutrophils and monocytes.
Similarity:	Contains 1 disintegrin domain.
Similarity:	Contains 1 EGF-like domain.
Similarity:	Contains 1 peptidase M12B domain [view classification].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0,05 mg

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