Comparison

CD30

Item no. 18-272-195093
Manufacturer GENWAY
Amount 0.025 mg
Category
Type Antibody
Applications WB, ELISA
Specific against other
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias GWB-630C59
Similar products 18-272-195093
Available
Genway ID:
GWB-630C59
Isotype:
IgG
Immunogen:
Recombinant extracellular domain (Human) expressed in insect Sf 21 cells.
Antigen Species:
Human
Target:
CD30
Localization:
Type I membrane protein (long isoform); cytoplasmic (short isoform).
Concentration:
0. 1 mg/ml Storage
Preservative:
NoneConstituents: PBS
Application Note:
ELISA: Use at a concentration of 0. 5 - 1 µ g/ml. This concentration detects a limit of approximately 0. 16 ng/well of human CD30. WB: Use at a concentration of 0. 1 - 0. 2 µ g/ml. This concentration detects human CD30 at approximately 5 ng/lane and 25 ng/lane under non-reducing and reducing conditions respectively. Detects a band of approximately 100-110 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. Cellular
Localization:
Type I membrane protein (long isoform); cytoplasmic (short isoform). CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation activation differentiation and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkins disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkins and Reed- Sternberg cells CD30 is also found in some non-Hodgkins lymphomas (including Burkitts lymphomas) virus-infected T and B cells and on normal T and B cells after activation. In T cells CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor.
Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Subunit:
Interacts with TRAF1 TRAF2 TRAF3 and TRAF5.
Subcellular Location:
Isoform Long: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform Short: Cytoplasm.
Ptm:
Phosphorylated on serine and tyrosine residues.
Disease:
Most specific Hodgkin disease associated antigen.
Similarity:
Contains 6 TNFR-Cys repeats.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.025 mg
Available: In stock
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