Alpha-fetoprotein (C-Term)

A synthetic peptide corresponding to residues in C-terminus of human AFP was used as an immunogen.

WB: 1:5 000IHC: 1:100-250. Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal ovarian pancreatic testicular and certain liver cancers. High level of AFP is also seen some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently AFP has been introduced as an anti-cancer drug-ligand carrier transporting drugs to target tumor cells increasing anti-tumor efficiency (3). 1. Wang XW et al. World J Gastroenterol 7:345-351 2001. 2. Chen H et al. Crit Rev Eukaryot Gene Expr 7:11-41 1997. 3. Zheng AI et al. CJC 22:108-111 2003. 4. Manufactured under U. S. Patents No. 5 675 063 and 7 429 487