AKAP10

06-202-340422 - Immunizing Peptide

0. 3-1ug/ml. Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This protein is a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction. [provided by RefSeq]. [1] Yoshida T. Kato K. Fujimaki T. Yokoi K. Oguri M. Watanabe S. Metoki N. Yoshida H. Satoh K. Aoyagi Y. Nishigaki Y. et al. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome[2] Yoshida T. Yajima K. Hibino T. Kato K. Matsuo H. Segawa T. Watanabe S. Oguri M. Yokoi K. Nozawa Y. Kimura G. and Yamada Y. Association of gene polymorphisms with myocardial infarction in individuals with different lipid profiles[3] Tingley W. G. Pawlikowska L. Zaroff J. G. Kim T. Nguyen T. Young S. G. Vranizan K. Kwok P. Y. Whooley M. A. and Conklin B. R. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation[4] Wirtenberger M. Schmutzhard J. Hemminki K. Meindl A. Sutter C. Schmutzler R. K. Wappenschmidt B. Kiechle M. Arnold N. et al. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer[5] Nishihama K. Yamada Y. Matsuo H. Segawa T. Watanabe S. Kato K. Yajima K. Hibino T. Yokoi K. Ichihara S. Metoki N. et al. Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors