GIRK2 / KCNJ6

06-202-340311 - Immunizing Peptide

1-3ug/ml. An additional band of unknown identity was also consistently observed at 35kDa. This band was successfully blocked by incubation with the immunising peptide. Summary: Potassium channels are present in most mammalian cells where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein which has a greater tendency to allow potassium to flow into a cell rather than out of a cell is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [1] Ji W. Foo J. N. O\' Roak B. J. Zhao H. Larson M. G. Simon D. B. Newton-Cheh C. State M. W. Levy D. and Lifton R. P. Rare independent mutations in renal salt handling genes contribute to blood pressure variation[2] Lignon J. M. Bichler Z. Hivert B. Gannier F. E. Cosnay P. del Rio J. A. Migliore-Samour D. and Malecot C. O. Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21[3] Saccone S. F. Hinrichs A. L. Saccone N. L. Chase G. A. Konvicka K. Madden P. A. Breslau N. Johnson E. O. Hatsukami D. Pomerleau O. et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs[4] Hu Y. H. Warnatz H. J. Vanhecke D. Wagner F. Fiebitz A. Thamm S. Kahlem P. Lehrach H. Yaspo M. L. and Janitz M. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins[5] Kubo Y. Adelman J. P. Clapham D. E. Jan L. Y. Karschin A. Kurachi Y. Lazdunski M. Nichols C. G. Seino S. and et al. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels