VPS26A

GWB-438B3D

Peptide with sequence C-SPESQASAEQPEM from the C Terminus of the Notes: Peptide ELISA: antibody detection limit dilution 1/4 000. Western Blot: Approx 40kDa band observed in Human Kidney lysates (predicted size of approx. 38kDa according to NP_004887. 2). Recommended for use at 1-2ug/ml. Summary: This protein belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex termed the retromer complex involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35 which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [1] Riemenschneider M. Schoepfer-Wendels A. Friedrich P. Konta L. Laws S. M. Mueller J. C. Kurz A. and Forstl H. No association of vacuolar protein sorting 26 polymorphisms with Alzheimer\' s disease[2] Rojas R. Kametaka S. Haft C. R. and Bonifacino J. S. et al. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors[3] Shi H. Rojas R. Bonifacino J. S. and Hurley J. H. et al. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain[4] Gullapalli A. Wolfe B. L. Griffin C. T. Magnuson T. and Trejo J. et al. An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer- Hrs- and Tsg101-independent functions of sorting nexins[5] Small S. A. Kent K. Pierce A. Leung C. Kang M. S. Okada H. Honig L. Vonsattel J. P. and Kim T. W. Model-guided microarray implicates the retromer complex in Alzheimer\' s disease