COP1 / PSEUDO-ICE (Isofom 2)

GWB-564B0D

Peptide with sequence C-ETLGLSAGPIPGN from the C Terminus of the Notes: Peptide ELISA: antibody detection limit dilution 1:4 000. Western Blot: Preliminary experiments gave an approx 28-30kDa band in human colon pancreas placenta and tonsil lysates after 0. 3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 10. 7kDa according to NP_443121. 1. The 28-30kDa band was successfully blocked by incubation with the immunizing peptide. [1] Wang X. Narayanan M. Bruey J. M. Rigamonti D. Cattaneo E. Reed J. C. and Friedlander R. M. Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death[2] Wang X. Wang H. Figueroa B. E. Zhang W. H. Huo C. Guan Y. Zhang Y. Bruey J. M. Reed J. C. and Friedlander R. M. Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington\' s disease[3] Lamkanfi M. Denecker G. Kalai M. D\' hondt K. Meeus A. Declercq W. Saelens X. and Vandenabeele P. INCA a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation[4] Razmara M. Srinivasula S. M. Wang L. Poyet J. L. Geddes B. J. DiStefano P. S. Bertin J. and Alnemri E. S. CARD-8 protein a new CARD family member that regulates caspase-1 activation and apoptosis[5] Lee S. H. Stehlik C. and Reed J. C. et al. Cop a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing