Tensin 1 / TNS1

GWB-3F9B1E

Peptide with sequence C-VSKVMLNAGQKR from the C Terminus of the p Notes: Peptide ELISA: antibody detection limit dilution 1:2 000. Western Blot: Preliminary experiments in Human Heart Kidney and Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml). Summary: The protein encoded by this gene localizes to focal adhesions regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described but its full length nature has not been determined. [provided by RefSeq]. [1] Saintigny G. Bernard F. X. Juchaux F. Pedretti N. and Mahe C. et al. Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction[2] Eto M. Kirkbride J. Elliott E. Lo S. H. and Brautigan D. L. et al. Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions[3] Liao Y. C. Si L. deVere White R. W. and Lo S. H. et al. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1[4] Olsen J. V. Blagoev B. Gnad F. Macek B. Kumar C. Mortensen P. and Mann M. Global in vivo and site-specific phosphorylation dynamics in signaling networks[5] Beaty T. H. Hetmanski J. B. Fallin M. D. Park J. W. Sull J. W. McIntosh I. Liang K. Y. Vanderkolk C. A. Redett R. J. et al. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations