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RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1)

RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1)

Item no.	18-003-44632
Manufacturer	GENWAY
Amount	0,1 mg
Type	Antibody
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-50DE34
Similar products	18-003-44632
Available
Genway ID:	GWB-50DE34
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of human RIPK1.
ELISA Titre:	1:15000
Category:	Tumor Suppressor Genes & Apoptosis
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. RIPK1 interacts with the death domain of FAS and TRADD and initiates apoptosis. It is recruited by TRADD to TNFR1 in a TNF- dependent process. Required for TNFR1 activation of NF-. B.
Function:	Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B.
Catalytic Activity:	ATP + a protein = ADP + a phosphoprotein.
Subunit:	Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3 UBCE7IP1 isoform 3 (ZIN) EGFR IKBKG TRAF1 TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1.
Subcellular Location:	Cytoplasm.
Ptm:	Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction.
Ptm:	Autophosphorylated on serine and threonine residues.
Similarity:	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:	Contains 1 death domain.
Similarity:	Contains 1 protein kinase domain. Hsu. H. . et al. . (1996) Immunity 4: 387-396.

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Amount: 0,1 mg

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Delivery expected until 9/27/2024