NPM1 (nucleophosmin (nucleolar phosphoprotein B23. numatrin))

GWB-4ADFEC

1:62500

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. NPM2 is a member of Nucleophosmin (NPM) family. NPM is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and cytoplasm. N/ASummary: NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions including ribosomal protein assembly and transport control of centrosome duplication and regulation of the tumor suppressor ARF (MIM 600160). NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia (AML; MIM 601626) (Garzon et al. 2008 [PubMed 18308931]). [supplied by OMIM]. Falini. B. . et al. . (2005) N. Engl. J. Med. 352 (3). 254-266.