TCFL1

Item no.	18-003-42469
Manufacturer	GENWAY
Amount	0.05 mg
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody
Applications	WB
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-FCA380
Similar products	18-003-42469
Available
Genway ID:	GWB-FCA380
Antigen Specificity:	Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human TCFL1.
ELISA Titre:	1:62500
Category:	Transcription Factor Antibodies
Note:	Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. TCFL1 encodes the YL-1 protein which is a subunit of the TRRAP/TIP60 HAT complex. and also is a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP.
Function:	Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.
Subunit:	Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit HTATIP/TIP60 and the subunits EP400 TRRAP/PAF400 BRD8/SMAP EPC1 DMAP1/DNMAP1 RUVBL1/TIP49 RUVBL2 ING3 actin ACTL6A/BAF53A MORF4L1/MRG15 MORF4L2/MRGX MRGBP YEATS4/GAS41 and VPS72/YL1. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ.
Subcellular Location:	Nucleus.
Ptm:	Phosphorylated upon DNA damage probably by ATM or ATR.
Similarity:	Belongs to the VPS72/YL1 family. Horikawa. I. . et al. . (1995) Oshimura. M. Biochem. Biophys. Res. Commun. 208 (3). 999-1007.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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