ZNFN1A2

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human ZNFN1A2.

Suggested starting concentrations are provided. Optimal dilutions should be determined by end-user. Differences in calculated versus apparent molecular weight may be due to post-translational modifications or protein hydrophobicity. Novel short isoforms of this gene. ZNFN1A2. are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Summary: This protein is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene but the biological validity of some variants has not been determined. Hahm. K. . et al. . (1998) Genes Dev. 12 (6). 782-96.