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RABBIT F(ab\&#039,)2 ANTI MOUSE CD194

RABBIT F(ab\&#039,)2 ANTI MOUSE CD194

Item no.	25-783-315810
Manufacturer	GENWAY
Amount	0.05 ml
Category	Oncology Antibodies By Cell Type Hematology Leukemia Lymphoma Western Blot Primary Antibodies
Type	Antibody
Applications	WB
Specific against	Mouse
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-69486E
Similar products	25-783-315810
Available
Genway ID:	GWB-69486E
Specificity:	CD194
Isotype:	Polyclonal IgGSpecies Cross Reactivity: Does not react with:Human
Buffer Solution:	KHPO4 pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3) 0. 1% Bovine Serum Albumin
Immunogen:	Synthetic peptide DTTQDETVYNSYYFYESMP-C corresponding to amino acids 8-26 of mouse CD194.
Specificity:	AAM66 specifically recognises mouse CD194 otherwise known as CCR4 (C-C chemokine receptor type 4) a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family preferentially expressed by CD4+ Th2 (type 2 helper T) cells which acts as a high affinity receptor for the chemokines MDC (macrophage-derived chemokine) MCP-1 MIP-1 RANTES and TARC. AAM66 is reported as suitable for use in immunocytochemistry on human peripheral blood leucocytes or Jurkat cells. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)
Function:	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS could mediate hippocampal-neuron survival. Ref. 3Subcellular locationCell membrane; Multi-pass membrane protein. Tissue specificityExpressed in the thymus macrophages and T- and B-cells. Developmental stageLow expression at 7. 5 dpc and 12. 5 dpc in the yolk sac. Post-translational modificationIn natural killer cells CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues most probably by beta-adrenergic receptor kinases 1 and 2 By similarity. Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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