Hamster Anti-Mouse CD69 (VEA)

Armenian Hamster IgG lambda

Y245 mouse dendritic epidermal T cell line 1

Mouse CD69/Very Early Activation Antigen (VEA) Mr 85 kDa (unreduced)CD69 also known as very early activation (VEA) antigen is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. 1 2 It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. 3 CD69 is widely expressed on hematopoietic cells including lymphocytes neutrophils and eosinophils. 1-4 Although not detectable on resting lymphocytes its expression is rapidly (within 2 hours) upregulated upon activation of T B and NK cells and neutrophils. 4 Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. 4 5 MAb H1. 2F3 augments PMA-induced T-cell proliferation 1 6 and induces redirected lysis of Fc receptor-bearing target cells by NK cells. 7

Flow Cytometry: 1 ug/10^6 cells