Rat Anti-Mouse CD38

GWB-E26E6B

NIMR-5

CD38 Mr 42-46 kDa Murine CD38 a type II transmembrane glycoprotein is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells a proportion of peripheral T cells and a subpopulation of thymocytes which are mostly TCR+ CD4- CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation protect B cells from apoptosis and inhibit B lymphopoiesis. 1-8

Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

NAD+ + H2O = ADP-ribose + nicotinamide.

Membrane; Single-pass type II membrane protein.

Belongs to the ADP-ribosyl cyclase family. 1. Harada N. L. Santos-Argumedo R. Chang J. C. Grimaldi F. E. Lund C. I. Brannan N. G. Copeland N. A. Jenkins A. W. Heath and R. M. Parkhouse. 1993. J. Immunol. 151:3111. 2. Santos-Argumedo L. C. Teixeira G. Preece P. A. Kirkham and R. M. E. Parkhouse. 1993. J. Immunol. 151:3119. 3. Howard M. J. C. Grimaldi J. F. Bazan F. E. Lund L. Santos-Argumedo R. M. E. Parkhouse T. F. Walseth and H. C. Lee. 1993. Science 262:1056. 4. Lund F. N. Solvason J. C. Grimaldi R. M. Parkhouse and M. Howard. 1995. Immunol. Today 16:469. 5. Kirkham P. A. L. Santos-Argumedo M. M. Harnett and R. M. Parkhouse. 1994. Immunology 83:513. 6. Bean A. G. D. D. I. Godfrey W. G. Ferlin L. Santos-Argumedo R. M. E. Parkhouse M. C. Howard and A. Zlotnik. 1996. Int. Immunol. 7:213. 7. Oliver A. and J. Kearney. 1996. Personal Communication. 8. Kumagai M. E. Coustan-Smith D. J. Murray O. Silvennoinen K. G. Murti W. E. Evans F. Malavasi and D. Campana. 1995. J. Exp. Med. 181:1101.