RAT ANTI MOUSE CD19:APC

GWB-E044DB

IgG2a

Phosphate buffered saline pH7. 4

Human K562 cell line transfected with murine CD19

Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Subunit structureForms a complex with CD21 CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-346 and/or Tyr-376. Interacts with PLCG2 when phosphorylated on Tyr-402 By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Post-translational modificationPhosphorylated upon DNA damage probably by ATM or ATR By similarity. Ref. 5Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Nakagawa Y. (2004) Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor. Biol. Pharm. Bull. 27: 956-960. [1] \" Cloning and sequencing of the cDNA encoding a phospholipid hydroperoxide glutathione peroxidase. \" Nam S. -Y. Nakamuta N. Kurohmaru M. Hayashi Y. Gene 198:245-249(1997) [PubMed: 9370288] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. Tissue: Testis. [2] \" Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene. \" Borchert A. Schnurr K. Thiele B. J. Kuehn H. FEBS Lett. 446:223-227(1999) [PubMed: 10100845] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6N. [3] \" Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence tissue expression and mapping. \" Knopp E. A. Arndt T. L. Eng K. L. Caldwell M. LeBoeuf R. C. Deeb S. S. O\' Brien K. D. Mamm. Genome 10:601-605(1999) [PubMed: 10341094] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: BALB/c and C57BL/6J. Tissue: Myocardium and Testis. [4] \" Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. \" Imai H. Hirao F. Sakamoto T. Sekine K. Mizukura Y. Saito M. Kitamoto T. Hayasaka M. Hanaoka K. Nakagawa Y. Biochem. Biophys. Res. Commun. 305:278-286(2003) [PubMed: 12745070] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver. [5] \" The transcriptional landscape of the mammalian genome. \" Carninci P. Kasukawa T. Katayama S. Gough J. Frith M. C. Maeda N. Oyama R. Ravasi T. Lenhard B. Wells C. Kodzius R. Shimokawa K. Bajic V. B. Brenner S. E. Batalov S. Forrest A. R. Zavolan M. Davis M. J. Wilming L. G. Aidinis V. Allen J. E. Ambesi-Impiombato A. Apweiler R. Aturaliya R. N. Bailey T. L. Bansal M. Baxter L. Beisel K. W. Bersano T. Bono H. Chalk A. M. Chiu K. P. Choudhary V. Christoffels A. Clutterbuck D. R. Crowe M. L. Dalla E. Dalrymple B. P. de Bono B. Della Gatta G. di Bernardo D. Down T. Engstrom P. Fagiolini M. Faulkner G. Fletcher C. F. Fukushima T. Furuno M. Futaki S. Gariboldi M. Georgii-Hemming P. Gingeras T. R. Gojobori T. Green R. E. Gustincich S. Harbers M. Hayashi Y. Hensch T. K. Hirokawa N. Hill D. Huminiecki L. Iacono M. Ikeo K. Iwama A. Ishikawa T. Jakt M. Kanapin A. Katoh M. Kawasawa Y. Kelso J. Kitamura H. Kitano H. Kollias G. Krishnan S. P. Kruger A. Kummerfeld S. K. Kurochkin I. V. Lareau L. F. Lazarevic D. Lipovich L. Liu J. Liuni S. McWilliam S. Madan Babu M. Madera M. Marchionni L. Matsuda H. Matsuzawa S. Miki H. Mignone F. Miyake S. Morris K. Mottagui-Tabar S. Mulder N. Nakano N. Nakauchi H. Ng P. Nilsson R. Nishiguchi S. Nishikawa S. Nori F. Ohara O. Okazaki Y. Orlando V. Pang K. C. Pavan W. J. Pavesi G. Pesole G. Petrovsky N. Piazza S. Reed J. Reid J. F. Ring B. Z. Ringwald M. Rost B. Ruan Y. Salzberg S. L. Sandelin A. Schneider C. Schoenbach C. Sekiguchi K. Semple C. A. Seno S. Sessa L. Sheng Y. Shibata Y. Shimada H. Shimada K. Silva D. Sinclair B. Sperling S. Stupka E. Sugiura K. Sultana R. Takenaka Y. Taki K. Tammoja K. Tan S. L. Tang S. Taylor M. S. Tegner J. Teichmann S. A. Ueda H. R. van Nimwegen E. Verardo R. Wei C. L. Yagi K. Yamanishi H. Zabarovsky E. Zhu S. Zimmer A. Hide W. Bult C. Grimmond S. M. Teasdale R. D. Liu E. T. Brusic V. Quackenbush J. Wahlestedt C. Mattick J. S. Hume D. A. Kai C. Sasaki D. Tomaru Y. Fukuda S. Kanamori-Katayama M. Suzuki M. Aoki J. Arakawa T. Iida J. Imamura K. Itoh M. Kato T. Kawaji H. Kawagashira N. Kawashima T. Kojima M. Kondo S. Konno H. Nakano K. Ninomiya N. Nishio T. Okada M. Plessy C. Shibata K. Shiraki T. Suzuki S. Tagami M. Waki K. Watahiki A. Okamura-Oho Y. Suzuki H. Kawai J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Testis. [6] \" The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. \" Yant L. J. Ran Q. Rao L. Van Remmen H. Shibatani T. Belter J. G. Motta L. Richardson A. Prolla T. A. Free Radic. Biol. Med. 34:496-502(2003) [PubMed: 12566075] [Abstract]Cited for: FUNCTION. [7] \" Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. \" Seiler A. Schneider M. Foerster H. Roth S. Wirth E. K. Culmsee C. Plesnila N. Kremmer E. Raadmark O. Wurst W. Bornkamm G. W. Schweizer U. Conrad M. Cell Metab. 8:237-248(2008) [PubMed: 18762024] [Abstract]Cited for: DISRUPTION PHENOTYPE FUNCTION. [8] \" Mitochondrial glutathione peroxidase 4 disruption causes male infertility. \" Schneider M. Forster H. Boersma A. Seiler A. Wehnes H. Sinowatz F. Neumueller C. Deutsch M. J. Walch A. Hrabe de Angelis M. Wurst W. Ursini F. Roveri A. Maleszewski M. Maiorino M. Conrad M. FASEB J. 23:3233-3242(2009) [PubMed: 19417079] [Abstract]Cited for: DISRUPTION PHENOTYPE FUNCTION TISSUE SPECIFICITY.